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Product Name Gotu Kola extract powder Total triterpenes (Asiaticoside +Madecassoside)
Botanical Name Centella Asiatica
Synonyms luei gong gen, fo-ti-tieng, Hydrocotyle asiatica, Centella asiatica,  longevity herb , Herba Centellae, pegaga, Brahmi, Chi-hsueh Ts'ao, Indian Pennywort, Brahma-manduki, Marsh penny, Water pennywort
Part Used Whole plant
Active Ingredient triterpenes,Asiaticoside,Madecassoside
CAS No. 16830-15-2, 34540-22-2
Molecular Formula C48H78O19, C48H78O20
Specification 4:1, 10:1, 20% / 40% / 80% Total Triterpenoid glycosides,10%, 20%, 30%,80% Asiaticoside/Madecassoside
Related ingredients Ginseng,Ginkgo Biloba, Ayurvedic medicine
Main benefits Wound healing, reduce depression, and high blood pressure, longevity

 What is Gotu Kola extract?

 The Gotu Kola is also a traditional herb in China, India, Sri Lanka and Indonesia, and is being introduced as a cultivated vegetable in developed countries. In China, It is called luei gong gen, or Ji Xue Cao in Chinese Pinyin.  Popularity of Centella asiatica is mostly due to its efficacy and versatility, especially referring to its reputation as a wound healing agent and brain stimulant (promoting brain growth and improving learning and memory). Many scientists in the world have been conducting quite extensive experimental and clinical investigations and focusing their interests on searching for some promising compounds with high effectiveness and low toxicity for the benefit of human's health. XYsShanghai Natural Bio-engineering Co., Ltd

History of Gotu Kola

Historically, it is believed that Rakoto Ratsimamanga, a scientist from Madagascar, popularized knowledge about the medicinal properties of gotu kola when he first published results (in the 1950s) of a small clinical trial utilizing the herb. In fact, two of the most biologically active constituents of gotu kola (madecassic acid and madecassoside) are named for Madagascar. Other beneficial phytochemicals include additional triterpene glycosides (i.e., asiaticoside) and asiatic acid (which also forms in the human body from asiaticoside). These components exhibit antioxidant and anti-inflammatory properties.XYsShanghai Natural Bio-engineering Co., Ltd Malagasy traditional healers utilized the dried leaves of gotu kola to treat a variety of conditions, including asthma, leprosy, bronchitis, and syphilis. It was also used for insanity in Brazil, and to improve brain function, metabolism, and the immune system in India.XYsShanghai Natural Bio-engineering Co., Ltd In Sri Lanka, gotu kola has a reputation for promoting longevity—possibly because it is a diet staple of Sri Lankan elephants, who are long-lived.This animal connection is reflected in India as well, where gotu kola is also called tiger’s grass because tigers are known to roll themselves on it after fighting—presumably because of the herb's wound-healing properties. Li Ching-Yuen, as a Chinese Herbalist,the oldest man in the wolrd, has lived to the age of 256 years, is said to be closed with gotu Cola.XYsShanghai Natural Bio-engineering Co., Ltd

Chemical constituents of Centella asiatica

Based on numerous studies, the biologically active ingredients are believed to be its triterpenes, which enhance the formulation of collagen in bones, cartilage and connective tissue and the medicinal values of this plant are mainly attributed to the presence of several triterpenes, namely asiatic acid, madecassic acid, asiaticoside and madecassoside. Triterpenes being the major components of Centella Asiatica, they have been regarded as its biomarker components. Stimulation of hyaluronic acid and increased chondroitin sulphate was seen after incorporation of the total triterpene fraction of Centella asiatica into human embryonic fibroblast. The most important constituents are the triterpenoid saponins, including asiaticoside, centelloside, madecassoside, and asiatic acid. In addition, Centella contains other components, including volatile oils, flavonoids, tannins, phytosterols, amino acids, and sugars.XYsShanghai Natural Bio-engineering Co., Ltd

Mechanisms of Action of Gotu Kola extract(Centella asiatica)

Centella has several pharmacological actions, based primarily on in vivo experiments. After oral and topical administration in rats, increased cellular hyperplasia and collagen production were noted at the site of injury, measured by increased granulation tissue levels of DNA, protein, total collagen, and hexosamine. More rapid maturation and cross-linking of collagen were seen in animals treated with the herbal extract, as evidenced by elevated stability of acidsoluble collagen and increases in aldehyde content and tensile strength. Compared to control wounds, rats treated with gotu kola had a higher degree of epithelialization and a significantly more rapid rate of wound contraction.XYsShanghai Natural Bio-engineering Co., Ltd In addition to improving wound healing, Centella may also have an effect on connective tissue of varicosities. After receiving 30 mg total triterpenoid fraction of Centella asiatica (TTFCA) twice daily for three months, individuals with varicose veins had significantly reduced serum enzymes involved in mucopolysaccharide metabolism (betaglucuronidase, beta-N-acetylglucosaminidase, and arylsulfatase) compared to baseline values (p<0.01).XYsShanghai Natural Bio-engineering Co., Ltd The capacity to regenerate axons is an important component of healing following nerve damage. Rats given Centella extract in their drinking water recovered more quickly after nerve damage than controls, with increased axonal regeneration and more rapid functional recovery.XYsShanghai Natural Bio-engineering Co., Ltd The fresh juice extract of gotu kola at 200 and 600 mg/kg twice per day has proven to be protective against aspirin- and ethanol-induced gastric ulcers, with similar effects as the medication sucralfate. Centella significantly induced gastric mucin secretion and mucosal cell glycoprotein production, markers of increased gastric mucosal defense factorsXYsShanghai Natural Bio-engineering Co., Ltd

Benefits of taking Gotu Kola extract supplements

Gotu Kola has been used in traditional Chinese medicine systems for thousands of years to treat a wide variety of ailments and conditions. Healers have used Centella asiatica to treat a variety of ailments for thousands of years including leprosy, eczema, psoriasis, respiratory infections, ulcers, colds, hepatitis, epilepsy, fatigue, fevers, asthma and syphilis. In Chinese medicine, Centella asiatica is also known as the "fountain of life" herb because it supposedly increases longevity. Though scientific study has yet to prove the efficacy of gotu kola for these disorders, herbalists sometimes prescribe the herb for the treatment of insomnia, scleroderma, cancer, circulatory disorders, hypertension, memory loss, scars and cellulite.XYsShanghai Natural Bio-engineering Co., Ltd

Gotu Kola and Wound Healing

Gotu Kola has a component called triterpenoids, an element that have been proven to aid in healing wounds. Animal studies performed with the compound have shown that triterpenoids strengthen the skin while increasing the concentrated amount of antioxidants in the wounds. It also increase the blood supply around these areas, restoring tissue.XYsShanghai Natural Bio-engineering Co., Ltd Due to these healing properties, gotu cola has been used in the prevention of scar formation after a medical surgery, for burn victims, and for recovery of an episiotomy after childbirth.XYsShanghai Natural Bio-engineering Co., Ltd

Gotu Kola and Anxiety and depression

The compound found in gotu kola, known as triterpenoids, have displayed the ability of being able to increase mental acuity and decrease anxiety in mice. A newly-released study also showed that those who took gotu kola were less affected by novel noise, a precursor of anxiety. While these are promising results, the dosage used to get these conclusions were extremely high.XYsShanghai Natural Bio-engineering Co., Ltd

Gotu Kola and High Blood pressure

One study has shown that those that took abana (herbal mixture with gotu Kola) and had heart disease and high blood pressure encountered a large reduction in diastolic blood pressure. This is compared to those that simply took the placedo.XYsShanghai Natural Bio-engineering Co., Ltd

Side effects of taking gotu Kola extract

Not enough human research for any prolonged period has been done with Centella asiatica to know whether it is safe or whether it has side effects.XYsShanghai Natural Bio-engineering Co., Ltd

Gotu Kola Dosage

In adults, the recommended daily dose of TTFCAXYsShanghai Natural Bio-engineering Co., Ltd (or TECA) extracts standardized for asiaticoside, asiatic acid, and madecassic acid is 60-120 mg. The recommended daily dosages of crude herb andXYsShanghai Natural Bio-engineering Co., Ltd 1:5 tincture are 0.5-6 g and 10-20 mL, respectively.XYsShanghai Natural Bio-engineering Co., Ltd

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