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Product Name Dexamethasone
CAS 50-02-2
MF C22H29FO5
MW 392.46
mp 262.264°C(lit.)
alpha 75 º (c=1, dioxane)
refractive index 76 ° (C=1, Dioxane)
Package Packed in paper-drums and two plastic-bags inside. Size:35*51cm N.W.:25kgs/drum. G.w.:28kg/drum
Storage temp. 2-8°C
According to wikipedia, Dexamethasone is a type of steroid medication. It has anti-inflammatory and immunosuppressant effects. It is 25 times more potent than cortisol in its glucocorticoid effect, while having minimal mineralocorticoid effect.R2pShanghai Natural Bio-engineering Co., Ltd Dexamethasone is used for the treatment of many conditions including: rheumatologic problems, a number of skin diseases such as erythema multiforme, severe allergies, asthma, chronic obstructive lung disease, croup, and cerebral edema, in addition to other medications in tuberculosis and a number of other infectious diseases.R2pShanghai Natural Bio-engineering Co., Ltd It is pregnancy category C in the United States and class A in Australia, meaning it has been frequently used in pregnancy and not been found to cause problems for the baby.R2pShanghai Natural Bio-engineering Co., Ltd It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.R2pShanghai Natural Bio-engineering Co., Ltd

Medical use

Anti-inflammatoryR2pShanghai Natural Bio-engineering Co., Ltd Dexamethasone is used to treat many inflammatory and autoimmune conditions, such as rheumatoid arthritis and bronchospasm. Idiopathic thrombocytopenic purpura, a decrease in numbers of platelets due to an immune problem, responds to 40 mg daily for four days; it may be administered in 14-day cycles. It is unclear whether dexamethasone in this condition is significantly better than other glucocorticoids.R2pShanghai Natural Bio-engineering Co., Ltd It is also given in small amounts before and/or after some forms of dental surgery, such as the extraction of the wisdom teeth, an operation which often leaves the patient with puffy, swollen cheeks.R2pShanghai Natural Bio-engineering Co., Ltd It is injected into the heel when treating plantar fasciitis, sometimes in conjunction with triamcinolone acetonide.R2pShanghai Natural Bio-engineering Co., Ltd It is useful to counteract allergic anaphylactic shock, if given in high doses.R2pShanghai Natural Bio-engineering Co., Ltd It is present in certain eye drops – particularly after eye surgery – and as a nasal spray (trade name Dexacort), and certain ear drops (Sofradex, when combined with an antibiotic and an antifungal).R2pShanghai Natural Bio-engineering Co., Ltd Dexamethasone is used in transvenous screw-in cardiac pacing leads to minimize the inflammatory response of the myocardium. The steroid is released into the myocardium as soon as the screw is extended and can play a significant role in minimizing the acute pacing threshold due to the reduction of inflammatory response. The typical quantity present in a lead tip is less than 1.0 mg.R2pShanghai Natural Bio-engineering Co., Ltd Dexamethasone is often administered before antibiotics in cases of bacterial meningitis. It then acts to reduce the inflammatory response of the body to the bacteria killed by the antibiotics (bacterial death releases proinflammatory mediators that can cause a response which is harmful to the patient), thus improving prognosis and outcome.R2pShanghai Natural Bio-engineering Co., Ltd CancerR2pShanghai Natural Bio-engineering Co., Ltd Cancer patients undergoing chemotherapy are given dexamethasone to counteract certain side effects of their antitumor treatments. Dexamethasone can augment the antiemetic effect of 5-HT3 receptor antagonists, such as ondansetron.R2pShanghai Natural Bio-engineering Co., Ltd In brain tumors (primary or metastatic), dexamethasone is used to counteract the development of edema, which could eventually compress other brain structures. It is also given in cord compression, where a tumor is compressing the spinal cord.R2pShanghai Natural Bio-engineering Co., Ltd Dexamethasone is also used as a direct chemotherapeutic agent in certain haematological malignancies, especially in the treatment of multiple myeloma, in which dexamethasone is given alone or in combination with other chemotherapeutic drugs, including most commonly with thalidomide (Thal-dex), lenalidomide, bortezomib (Velcade, Vel-dex), or a combination of adriamycin (doxorubicin) and vincristine or velcade/revlimid/dexamethasone.R2pShanghai Natural Bio-engineering Co., Ltd EndocrineR2pShanghai Natural Bio-engineering Co., Ltd Dexamethasone is the treatment for the very rare disorder of glucocorticoid resistance.R2pShanghai Natural Bio-engineering Co., Ltd In adrenal insufficiency and Addison's disease, dexamethasone is prescribed when the patient does not respond well to prednisone or methylprednisolone.R2pShanghai Natural Bio-engineering Co., Ltd It can be used in congenital adrenal hyperplasia in older adolescents and adults to suppress ACTH production. It is typically given at night.R2pShanghai Natural Bio-engineering Co., Ltd PregnancyR2pShanghai Natural Bio-engineering Co., Ltd Dexamethasone may be given to women at risk of delivering prematurely to promote maturation of the fetus' lungs. This has been associated with low birth weight, although not with increased rates of neonatal death.R2pShanghai Natural Bio-engineering Co., Ltd Dexamethasone has been also been used during pregnancy as an off-label prenatal treatment for the symptoms of congenital adrenal hyperplasia (CAH) in female fetuses. CAH causes a variety of physical abnormalities, notably ambiguous genitalia in girls. Early prenatal CAH treatment has been shown to reduce some CAH symptoms, but it does not treat the underlying congenital disorder.R2pShanghai Natural Bio-engineering Co., Ltd A small clinical trial found long-term effects on verbal working memory among the small group of children treated prenatally, but the small number of test subjects means the study cannot be considered definitive. Administration of prenatal dexamethasone has been the subject of controversy over issues of informed consent and because treatment must predate a clinical diagnosis of CAH in the female fetus.R2pShanghai Natural Bio-engineering Co., Ltd High-altitude illnessesR2pShanghai Natural Bio-engineering Co., Ltd Dexamethasone is used in the treatment of high-altitude cerebral edema (HACE), as well as high-altitude pulmonary edema (HAPE). It is commonly carried on mountain-climbing expeditions to help climbers deal with complications of altitude sickness.R2pShanghai Natural Bio-engineering Co., Ltd SynergismR2pShanghai Natural Bio-engineering Co., Ltd Dexamethasone and ondansetron are more effective than ondansetron alone in preventing postoperative nausea and vomiting.R2pShanghai Natural Bio-engineering Co., Ltd

Synthesis

To synthesize dexamethasone, 16β-methylprednisolone acetate is dehydrated to the 9,11-dehydro derivative. This is then reacted with a source of hypobromite, such as basic N-bromosuccinimide, to form the 9α-bromo-11β-hydrin derivative, which is then ring-closed to an epoxide. A ring-opening reaction with hydrogen fluoride in tetrahydrofuran gives dexamethasone.R2pShanghai Natural Bio-engineering Co., Ltd

Nonmedical use

Dexamethasone is given in legal Bangladeshi brothels to prostitutes not yet of legal age, causing weight gain aimed at making them appear healthier and older to customers and police.R2pShanghai Natural Bio-engineering Co., Ltd Dexamethasone is a banned substance by some sporting bodies. In November 2014, the world's number one badminton player Lee Chong Wei was banned by the Badminton World Federation for testing positive for the drug, although he denied using any banned substances.R2pShanghai Natural Bio-engineering Co., Ltd

Veterinary use

Combined with marbofloxacin and clotrimazole, dexamethasone is available under the name Aurizon, CAS number 115550-35-1, and used to treat difficult ear infections, especially in dogs. It can also be combined with trichlormethiazide to treat horses with swelling of distal limbs and general bruising.R2pShanghai Natural Bio-engineering Co., Ltd

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