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Product name Olive leaf extract
Latin Name Olea Europaea L.
Source of Plant Mediterranean
Part Used Leaves
Active Ingredients Oleuropein,Hydroxytyrosol,Polyphenols
Specifications Oleuropein 20%, Oleuropein 40%, 
CAS NO 32619-42-4, 8060-29-5
Molecular Formula C25H32O13
Molecular Weight 540.4
Benefits enhance immune support, help cardiovascular health and antioxidant benefits
Dosage 500mg to 1600mg per day

What is Olive leaf extract?

Olive leaf extract, according to Wikipedia, comes from the leaves of olive tree (Olea europaea), and is distinct from Olive Oil; the leaf extract of olive herb contains phenolics such as oleuropein, and appears to have highly protective effects against LDL oxidation and may also benefit glucose metabolism and skin health. wDcShanghai Natural Bio-engineering Co., Ltd

Sources and chemical Composition of olive leaf extract

Olive leaf extract (Olea europaea) contains oleuropein and the flavonoids apigenin,  luteolin, chrysoeriol, hesperidin, rutin, quercetin, and kaempferol. Major isolated constituents strongly inhibit the classical pathway of the complement system. The primary medical constituents contained in unprocessed olive leaf are believed to be the antioxidants oleuropein and hydroxytyrosol, as well as several other polyphenols and flavonoids, including oleocanthal. Oleuropein was thought to give the olive tree its disease resistance.wDcShanghai Natural Bio-engineering Co., Ltd Oleuropein and its metabolite hydroxytyrosol have powerful antioxidant activity both in vivo and in vitroand give extra-virgin olive oil its bitter, pungent taste. Antioxidants are molecules that have the ability to inhibit the oxidation of other molecules. The oxidation reactions can produce free radicals. These free radicals can start a chain reaction in the cells which can cause damage and can lead to death. To fight free radicals, the body needs antioxidants such as Vitamin C, Vitamin E, glutathione, etc. And here comes the best part – recent study found that Olive leaf complex is 400% more potent antioxidant than Vitamin C.wDcShanghai Natural Bio-engineering Co., Ltd

Mechanism of Action of olive leaf extract oleuropein

 The cholesterol lowering effects of olive leaf extracts are thought to come from oleuropein, a substance contained within the leaf. Studies on hypercholesterolemic rats have shown that olive leaf extracts are more effective at lowering cholesterol than pure oleuropein. This implies that a synergistic effect occurs between oleuropein and another substance within the leaf. Oleuropein is converted into elenoic acid in the body which may prevent viruses and bacteria from replicating. The antihypertensive and vasodilating effects of olive leaf occurred independently of the integrity of the vascular endothelium. Constituents of olive leaf have been shown to strongly inhibit the complement system, although it is unknown what effect this has on the body. Hypoglycemic activities of olive leaf are attributed to two mechanisms: potentiation of glucose-induced insulin release and increased peripheral uptake of glucose. Hypoglycemic activity is greater in samples collected in the winter months. wDcShanghai Natural Bio-engineering Co., Ltd  Olive leaf extract has been shown to be effective against the following microorganisms: E. coli, Pseudomonas aeruginosa, S. aureus, K. pneumoniae, Trichophyton mentagrophytes, Microsporum canis, T. rubrum and Candida albicans. Anti-HIV properties of Olive leaf extract include up-regulation of the expression of apoptosis inhibitor proteins as well as protein kinase signaling molecules. Few trials in humans are available in the current literature. wDcShanghai Natural Bio-engineering Co., Ltd  Oleuropein works specifically against microbes in the following ways: wDcShanghai Natural Bio-engineering Co., Ltd  Interferes with certain amino acid production processes necessary to keep viruses alive. wDcShanghai Natural Bio-engineering Co., Ltd  Inactivates viruses by interfering with virus shedding, budding or assembly at the cellular membrane. wDcShanghai Natural Bio-engineering Co., Ltd  Penetrates infected host cells and inhibits viral replication. wDcShanghai Natural Bio-engineering Co., Ltd  Stimulates an immune system response, eliminating harmful microorganisms from the body. wDcShanghai Natural Bio-engineering Co., Ltd Benefits of taking olive leaf extract supplementwDcShanghai Natural Bio-engineering Co., Ltd The benefits of olive leaf extract have been well known in Mediterranean and Middle Eastern countries for centuries.  Olive Leaf Extract has many benefits including boosting insulin sensitivity and secretion, cardiovascular support, immune support, etc. The key benefits of olive leaf extracts are summarized as below:wDcShanghai Natural Bio-engineering Co., Ltd

1.Olive leaf extract with immune support

Your immune system is your coat of armor protecting your from many diseases and infections. When the immune system is working properly you do not suffer very long from cold, flu, and hundreds of other diseases . wDcShanghai Natural Bio-engineering Co., Ltd Symptoms of a weakened immune system:wDcShanghai Natural Bio-engineering Co., Ltd Allergies - Digestive problems – Fatigue - Joint – Poor appetite wDcShanghai Natural Bio-engineering Co., Ltd – Congestion - Respiratory problems – Rashes – Insomnia - Muscle weaknesswDcShanghai Natural Bio-engineering Co., Ltd Unlike antibiotics Olive Leaf does not build up immune system resistance.wDcShanghai Natural Bio-engineering Co., Ltd A strong immune system will recover from a pathogen invasion, and most of the time you will not be aware of the battle that took place within your body. However, if your immune system is not functioning at its peak efficacy, you may be sick for extended period of time. Once the immune system is over-burdened with some type of pathogen, (virus, fungi, yeast, bacteria, parasites) disease takes a foothold and sometimes it takes months and even years to manifest itself. In the meantime, the pathogens are in your body draining strength from the immune system. Olive Leaf does not cure any disease. It is, however a killer of many pathogens (Alternative Medicine Review). Once pathogens have been killed off, the immune system rebuilds itself ridding the body of disease symptoms.wDcShanghai Natural Bio-engineering Co., Ltd Olive leaf extract is a powerful antioxidant that boosts the immune system. Studies show that olive leaf extract is an immune system builder by directly stimulating phagocyte production (phagocytosis) - Phagocytosis is an immune system defense function. The cells called phagocytes ingest and kill invading organisms and cellular debris caused by tissue injury and dead cells.wDcShanghai Natural Bio-engineering Co., Ltd

2. Olive leaf extract with Cardiovascular health

Olive leaves have a long history of use as a herbal tonic to support cardiovascular function. Here naturopath Jayne Tancred explains that their traditional reputation may be at least partially due to its beneficial effects on the blood vessels.wDcShanghai Natural Bio-engineering Co., Ltd

3. Olive leaf extract and its antioxidant property 

Antioxidants play an essential role in the body as they quench free radicals. By damaging healthy cells, free radicals can leave the body vulnerable to advanced ageing, cardiovascular problems and degenerative diseases.wDcShanghai Natural Bio-engineering Co., Ltd Free radicals cause oxidation in the body, which is why antioxidants, like Vitamin C, Vitamin E and Olive Leaf Extract, play a major role in fighting free radicals.wDcShanghai Natural Bio-engineering Co., Ltd Are there many antioxidants available in olive leaf?wDcShanghai Natural Bio-engineering Co., Ltd The most active identified so for include: Oleuropein, Hydroxytyrosol& TyrosolwDcShanghai Natural Bio-engineering Co., Ltd

Oleuropein

The key to olive leaf is a phytochemical compound called Oleuropein from the leaves of Mission and Manzanillo olive trees. Oleuropein is the major phenolic constituent of the olive leaf (Olea europaea) and it is also present in olive oil and fruit. It has a powerful anti-bacterial and anti-viral effects. It has proven to be useful in cases of yeast and fungal infections, herpes, chronic fatigue, allergies, psoriasis and many other pathogens. Since it works like a broad-spectrum antibiotic, it is useful against colds, flu, and upper respiratory and sinus infections. In addition, it has been shown to lower blood sugar, normalize arrhythmias, inhibit oxidation of LDL (the bad cholesterol), and relax arterial walls, thereby helping to lower blood pressure. Other benefits are that it boosts energy and eases pain. Several compounds from olive leaves, oleuropein among them, have shown a variety of biological activities as an anti-microbial antioxidant.wDcShanghai Natural Bio-engineering Co., Ltd

Hydroxytyrosol

Hydroxytyrosol is believed to be one of the most powerful antioxidants. Its oxygen radical absorbance capacity is 40,000 umolTE/g, which is ten times higher than green tea. The antioxidant polyphenol is known for it's activity in preventing or reducing the deleterious effects of oxygen-derived free radicals associated with numerous inflammatory and stress-related human and animal diseases. It is also effective at inhibiting LDL oxidation associated with atherosclerosis.wDcShanghai Natural Bio-engineering Co., Ltd

Tyrosol

Tyrosol is a phenolic antioxidant. As an antioxidant, tyrosol can protect cells against injury due to oxidation.It's good bioavailability indicate that it may have an important overall effect. This effect may contribute significantly to the health benefits of the Mediterranean diet.wDcShanghai Natural Bio-engineering Co., Ltd

Resveratrol

Olive Leaf may be beneficial because of its oleuropein. Like the polyphenolic component of red wine, resveratrol, oleuropein imparts some important antioxidant benefits to the user including reduction of LDL oxidation. In fact, an argument can be made that oleuropein and resveratrol are high on the list of beneficial components of the highly touted Mediterranean Diet and account in large part for the reduced incidence of heart disease in those who habitually partake in the Diet.wDcShanghai Natural Bio-engineering Co., Ltd

Olive leaf extract side effects, safety, danger

There have not been any side effects reported yet with olive leaf extract supplement, but few human studies are available.wDcShanghai Natural Bio-engineering Co., Ltd

Dosage/toxicity of Olive leaf extract

Olive leaf extract has no known toxicity, and doses of 1,600 mg per day (divided into four 400 mg doses) have been administered with no significant side effectswDcShanghai Natural Bio-engineering Co., Ltd  wDcShanghai Natural Bio-engineering Co., Ltd

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